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Tryptophan catabolites and gut hormone secretion Indole has been seen to function as a signaling molecule, which is able to modulate the secretion of glucagon-like peptide-1 (GLP-1) from immortalized and primary mouse colonic enteroendocrine L cells 63

To assess the effect of senolytic drugs on human BM-MSC, several senolytic drugs were screened

Mitochondria contain 1015% of the intracellular GSH reaching a concentration of 1012 mM (54) while in the cytosol the concentration is 7 mM (54, 56)

It is also possible to bypass the BBB to achieve this goal

However, theres a caveat: the results only last for as long as the glutathione is consumed

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