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Optic Nerve Atrophy: Administering cyanocobalamin to patients with Leber's disease or hereditary optic nerve atrophy should be done cautiously, as it may worsen the condition

doi: 10.1146/annurev-virology-091919-100543 17 ZwickRKOhlsteinBKleinOD

Cellular health and healthy aging

On the other hand, Sappington et al

Qin XY, Cheng Y, Yu LC (2010) Potential protection of curcumin against intracellular amyloid -induced toxicity in cultured rat prefrontal cortical neurons