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Further research is also required to understand the mechanism by which oral glutamine enhances immunity in cancer patients and to determine whether glutamine should be administered to all patients undergoing chemotherapy or radiotherapy, as well as the potential use of glutamine metabolism inhibitors

This uncertainty creates a precautionary gap- both regulators and manufacturers may be cautious, delaying product approvals until more safety data are available

Accordingly, the unique genomic map of SARS-CoV-2 virus and the extent of its mediated virushost proteinprotein interactions that trigger human metabolic reprogramming and dysregulation (HMRD) in favor of the virus life cycle, defines the ultimate severity and fate of COVID-19 23,24,25,26

10.1016/j.toxlet.2014.04.011 54 LiS.TanH.-Y.WangN.ZhangZ.-J.LaoL.WongC.-W.et al (2015)

These four small G proteins bind to GTP/GDP and exhibit GTP hydrolase activity

J Biol Chem 1997, 272:182188