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A study showed that ferroptosis initiated APAP-induced liver injury, and ferroptosis inhibitors, such as ferrostatin-1 and iron chelator deferoxamine, alleviated APAP-induced liver injury ( + T cells by inhibiting ferroptosis ( Chronic liver injury refers to long-term and chronic damage to liver function caused by multiple factors, and it is mainly seen in chronic viral hepatitis, long-term heavy drinking, and fatty liver

[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Caldern-Ospina C.A., Nava-Mesa M.O.B

A significant finding is its effect in pathological scarring models, such as keloids, where it promoted apoptosis in resistant fibroblasts and reduced cell proliferation during the G0/G1 phase of the cell cycle

J Pharmacol Sci 113(4):395403

84 , 89 , 93 Hyperlactacidemia and an increased lactate/pyruvate ratio may result from several inherited metabolic defects of gluconeogenesis, pyruvate oxidation, the Krebs cycle, or the respiratory chain

All participants followed a calorie-restricted diet (~300 kcal/day deficit)