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Zhang J, Pavlova NN,Thompson CB

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A significant advantage of this method, when compared to other in vitro-derived effect concentrations, such as the minimum effect concentration (MEC) or the lowest observed effect concentration (LOEC), is that BMD modeling utilizes all data contained in a concentrationresponse curve and accounts for variability in control values

Apply it in the morning and evening to achieve the best results

The C57Bl/6J strain, which is most often used for drug toxicity studies, has an average susceptibility to an APAP overdose [128]

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