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These reactive astroglial changes are implicated in senile plaques at the early to moderate stage of AD during mild cognitive impairment and in the late stage of the disease during severe dementia (Verkhratsky et al., 2019a,b)

After thawing, cells were filtered through EASYstrainer 40 m (Greiner), washed with PBS and cultivated in RPMI-1640 (Gibco) supplemented with 10% fetal bovine serum (FBS-12A, Capricorn Scientific), 200 U/mL penicillin and 200 g/mL streptomycin (Gibco)

* Correspondence: Peina Zhou, [email protected]

Because the antibody titer was not normally distributed based on Levenes test, non-parametric KruskalWallis and MannWhitney tests were used to assess the statistical differences between groups

Abstract HIV-1 is a retrovirus that integrates into host chromatin and can remain transcriptionally quiescent in a pool of immune cells

No increase in number of adverse events with increasing renal or hepatic impairment was observed, and no new safety or tolerability findings with cagrilintide were identified with renal or hepatic impairment