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Phase I metabolism, as a general rule, generates very reactive oxidising compounds

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Litwack G, Ketterer B and Arias IM

To better understand how we might stimulate the FXN gene, a recent study evaluated which regions of the FXN promoter sequence were essential for gene expression

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Second, lysosomes are involved in the release and reuse of iron through their internal acidic environment and abundance of hydrolytic enzymes (Hung et al., Even so, multiple research suggests that by promoting the activity of the antioxidant gene superoxide dismutase 1 (SOD1), activating the nuclear transcription factor EB (TFEB) may prevent lysosome-based ferroptosis