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Starting at the lowest possible dose and escalating more slowly than standard protocols helps identify tolerance issues before reaching problematic dose levels

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Bristol-Myers Squibb, 2000

All experimental work was executed in accordance with the guiding principles of the Institute of Laboratory Animal Resources, Commission on Life Sciences University, National Research Council (1996), and was accepted by the Ethical Committee of the Riphah Institute of Pharmaceutical Sciences (Ref

Indeed, it was also shown that S-glutathionylation of Sdh is required to protect the enzyme complex from oxidative deactivation

Metabolic communication by SGLT2 inhibition