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doi: 10.4103/1673-5374.339003 9 ChenQ.WuM.TangQ.YanP.ZhuL

Altogether, IGF-1 signaling produces renal hypertrophy and increases glomerular filtration rate (GFR)

It also helps with the growth of probiotics (good bacteria) in the gut and supports healthy inflammation levels in the digestive tract

Calorie intake is not as crucial as nutritional quality

Therefore, close structural derivatives with a varying degree of G protein signaling efficacy are needed for direct and rigorous probing of this hypothesis