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AMPK activation leads to the suppression of hepatic lipid accumulation, thereby addressing one of the key features of NAFLD

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Moreover, RS004 (Horning et al., 2016) and 4-chloro-3-ethynylpyridine (Sen et al., 2019) were also reported to compete with NAM for binding by covalently linking to Cys165 and Cys159 in the active site of NNMT