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Protective effect of captopril against clozapine-induced myocarditis in rats: role of oxidative stress, proinflammatory cytokines and DNA damage

180, 181 AG-211 has since been introduced into Phase I clinical trials and a Phase III trial has been initiated in 2015

PMC 2543061

Diagnostic methods The level of 5-oxoproline in urine can be determined by gas chromatography-mass spectrometry [26]

Moderate glutathione synthetase deficiency Patients with the moderate variant usually present in the neonatal period with severe and chronic metabolic acidosis, 5-oxoprolinuria, and mild/moderate hemolytic anemia

GSH has a central participation in trans- hydrogenation reactions needed to maintain a reduced state of sulfhydryl groups of other molecules, proteins and enzymes, as well as formation of deoxyribonucleotides and vitamin reduction (15)