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Description

Intestinal oxidative damage in inflammatory bowel disease: semiquantification, localization, and association with mucosal antioxidants

In the nucleus, Nrf2 interacts with small Maf proteins (sMAF) and binds to antioxidant response elements (ARE), promoting the transcription of downstream antioxidant genes (Yan et al., 2023)

It downregulates nNOS mRNA expression confirmed by real-time polymerase chain reaction (RT-PCR)

REFERENCES [i] Kontos AP et al

Conclusions The results from this study showed that blood GSSG, MDA, homocysteine, SAH, nitric oxide, and copper concentrations were significantly increased, whereas GSH, tGSH, GSH/GSSG, tGSH/GSSG, SAM/SAH, methionine, cysteine, vitamins (B9, B12, D, and E), and calcium concentrations were significantly reduced in children with ASD