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Flavonoids constitute another type of chemical agent with immunomodulatory activities

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In fact, research on CBD has demonstrated that it affects how redox-sensitive transcription factors like nuclear factor erythroid 2related factor 2 (Nrf2) are controlled in microglia (87), keratinocytes (88) and endothelia (89), It is critical because Nrf2 is necessary for cytoprotective and antioxidant gene transcription to begin (90)

As mentioned above, -syn can interfere with translocation of mitochondrial-target proteins, thereby disrupting the proper functioning of the ETC, and leading to elevated levels of intracellular oxidative stress (Di Maio et al., 2016)