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The authors acknowledged that the study was short and also did not include a placebo arm, because providing the placebo form of sublingual vitamin B12 was very difficult

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In people with major depressive disorder and a chronic physical condition, mitochondrial ATP production decreases in muscle cells.[ref] Another post-mortem study on the brains of patients with depression, bipolar, or schizophrenia showed a specific mitochondrial protein (NDUFS7) involved in ATP production decreased significantly in patients with bipolar disorder.[ref] Ketogenic diet: A ketogenic diet is very low in carbohydrates, which causes a shift in the way that mitochondria produce energy

Bloating on tirzepatide is another common complaint that usually improves with dietary adjustments, particularly reducing fatty and highly processed foods that the slowed digestive system struggles to process efficiently