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As expected, mice on a high-fructose diet were protected against APAP hepatotoxicity, but deletion of Chrebp resulted in increased necrosis and liver ROS as well as elevated serum ALT and LDH levels [53] , confirming that fructose protection against APAP hepatotoxicity is mediated through the ChREBP-FGF21 axis [53]

Prognostic value of 18F-FDG PET/CT before and after radiotherapy for locally advanced nasopharyngeal carcinoma

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This pKa, usually around 9, is lowered to approximately 6.5 or even less, promoting the formation of a nucleophilic (reactive) thiolate group in vivo , which is able to perform a nucleophilic attack on a nearby electrophilic substrate