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In addition, 61.2% (90/147) of the downregulated proteins were assigned to catalytic activity

The identification of nongenetic factors underlying regionspecific SOD1 misfolding and deposition in SOD1 linked familial ALS, which may also contribute to wildtype SOD1 misfolding in sporadic ALS, idiopathic Parkinson's disease and potentially Alzheimer's disease will significantly improve our understanding of the biology of this protein