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10.3389/fbioe.2022.866195 [DOI] [PMC free article] [PubMed] [Google Scholar] Wang J., Zhu Q., Cao D., Peng Q., Zhang X., Li C., et al

RS-202300245081)

In the case of intrinsic apoptosis, which is mainly associated with mitochondrial dysfunction or ER stress, ROS can activate the cell cycle regulators p53 and JNK, which induce pro-apoptotic Bcl-2 family proteins such as Bak and Baxantagonists to anti-apoptotic proteins Bcl-xL and Bcl-2 in the outer mitochondrial membrane (OMM)eventually causing mitochondrial outer membrane permeabilization and subsequent apoptosis [136, 137]

Au NPs also decreased GEM resistance in cancer (420)

Cancer Lett 239(2):271280 Huang W-H, Lee A-R, Yang C-H (2006) Antioxidative and anti-inflammatory activities of polyhydroxyflavonoids of Scutellaria baicalensis GEORGI

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