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169-172 Cocaine use by gravid women complicates pregnancy and negatively affects post-partum development of the child

Precisely, superoxide anion and hydrogen peroxide have been reported to act as mitogens, thereby promoting the rate of DNA replication and cell proliferation in a variety of cultured cells.9, 10 Nonetheless, in excess amounts, oxygen-derived radicals are very harmful to living organisms

13 C-labeled metabolomics analysis Metabolites were extracted in ice-cold acetonitrile:methanol:water (40%:40%:20%, v:v:v) at a concentration of 2 10 6 cells ml 1

This dependency makes them vulnerable to pharmacological inhibition of mitochondrial respiration, and multiple related agents have already entered clinical use or advanced clinical trials [516, 520]