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Internal states of the Nrf2-Keap1 complex support the hinge-latch hypothesis In the current literature the hinge-latch hypothesis is the leading hypothesis with much evidence pointing in that direction 2,3,23,34

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Mass spectrometry revealed significant upregulation of barrier function proteins (desmoglein-1, filaggrin), antioxidant enzymes (SOD1, glutaredoxin-1), and protease inhibitors