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While, in westernized societies, acne is a nearly universal skin disease afflicting up to 95 percent of teens, in some populations eating more traditional diets, not even single cases could be found

They provide strong proof that a compound has a direct biological effect on the target tissue, but they cannot tell us how that compound will behave when applied to human skin (where absorption, distribution, and metabolism add complexity)

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Aug 15 2010;82(4):361-8, 369

//// Nevertheless there is no medical evidence that injections of vitamin B12 promote health in anyone other than those who are suffering from a B12 deficiency

Moreover, medications for gastritis, such as proton pump inhibitors, have been reported to inhibit gastric acid production, which might also cause malabsorption of vitamin B 12 [18, 20]