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The review concluded that NNMT plays important roles in obesity and type 2 diabetes and validated 5-Amino-1MQ as a potent small-molecule NNMT inhibitor that reverses diet-induced metabolic changes, establishing it as a primary research tool for the NNMT pathway

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Speculation ranges from unacceptable kidney toxicity in humans to business decisions by Arrowhead Research (which pivoted to RNA interference therapeutics) to challenges with the regulatory pathway

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Sibutramine has only little clinical relevance as an antidepressant but enhances weight loss due to an increase in energy expenditure and inhibition of food intake (37)