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Production Flow Chat of SLU-PP-332 Protection Reaction Methyl 4-hydroxybenzoate reacts with tert-butyldimethylsilyl chloride (TBSCl) in N,N-dimethylformamide (DMF) to protect the phenolic hydroxyl group, forming Intermediate 1

Becatti M, Fucci R, Mannucci A, et al

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10.1016/0891-5849(93)90006-G 76

They are abundant in plant-based foods, including fruits, vegetables, cereals, and beverages, and comprise a complex group of over 8000 known compounds ( Based on the number of phenolic rings and structural linkages, they are commonly categorized into five main classes: tannins, lignans, phenolic acids, flavonoids, and stilbenes ( This review highlights the major classes of polyphenols, evaluated as secondary metabolites, along with methods used for their extraction and characterization