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10.1016/S0140-6736(19)32008-2 163 ZaccariaM.VarnierM.PiazzaP.NoventaD.ErmolaoA

A 2020 review in Diabetes Care noted that "the hypoglycaemic effect of IGF-1 has been exploited therapeutically in rare forms of insulin-receptor-defect syndromes, but the risk-benefit calculation differs fundamentally from use in euglycaemic individuals" [20]