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HuR/p38/MK2 Signaling Pathway In experimental studies in a mouse model of intraperitoneal transduction of HuR-RNAi lentivirus, suppression of HuR gene expression in mouse POI was shown to cause a significant reduction in inflammation (in infiltration of inflammatory cells, expression of pro-inflammatory genes, and reduction in serum cytokines) via the p38/MK2 signaling pathway (Xiong et al., 2017)

Kiefer JD, Myburgh R, Russkamp NF, Volta L, Guggisberg A, Abdelmotaleb O, et al

Photoaging, a major component of extrinsic aging, induces notable structural changes in the skin, such as shortening and thickening of collagen fibers, damage to elastic fibers, loss of type I collagen, and alterations in the ratio of collagen types within the dermis

GSH stems the activation of transcription factors, such as the NFKB'S, that switch on disease-linked genes, as in inflammatory disorders, Sepsis, infections and cancers