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Rabbits challenged with high concentrations of BFT show tissue damage and hemorrhage, an increase in IL-8 expression, NF-B activation, and disruption of the epithelial barrier ( BFT was the first bacterial effector reported to activate the -catenin-dependent gene expression ( c-Myc expression and cellular proliferation in the APC mutant cell lines HT29/C1 and SW480 ( destruction complex is a condition needed for BFT to induce -catenin-mediated effects

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Following the IVI of DL--aminoadipic acid into rabbit eyes, neovascularization was observed by fundus imaging

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