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Macrophages play a dual role during pulmonary tuberculosis in mice

Future efforts should also focus on identifying active TCM constituents and their molecular targets, systematically mapping their functional networks

3.2 Viral impact: network perturbation mechanisms of differential genes and pathways 3.2.1 Common disturbance mechanism Viruses, as key external disturbance factors in the immune cooperative network, achieve immune escape, replication, and spread by targeting core signaling nodes, regulating the expression of functional genes, and disrupting cooperative loops between modules

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The PPAR agonists rosiglitazone and pioglitazone were recently found to reduce the levels of 2-HG and H3K4me3 in the colon of mice with colitis and to regulate GSH and ROS levels in lamina propria lymphocytes by modulating GLS1/2-HG/H3K4me3 signaling in mouse models of colitis and asthma (52) ( Table 1 )