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Another switch is the shift from E-cadherin (a protein which links together the melanocytes to keratinocytes) to N-cadherin that insures cell-cell adhesion between melanoma cells with the production of melanoma cells adhesion molecules called Mel-CAM 23,24

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87 Older patients are more at risk for QT prolongation but are also more likely to have structural heart disease, drug interactions, and decreased drug clearance

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Doses above 1.5mg produce this effect in most subjects regardless of receptor sensitivity