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Further, MSCs from Igf1r flox/flox mice with Igf1r deleted by a Cre adenovirus in vitro , although recruited to the bone surface after implantation, were unable to differentiate into osteoblasts

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2.6 Potential shortcomings in the validity of pain behavioral assessments and animal models of CIPN These are commonly used and well-established animal behavioral assessments to evaluate pain-like behaviors in rodents, which closely resemble the clinical symptoms of CIPN observed in patients

At higher quantities, mild hypotension and a temporary decrease in concentration have been described in individual observations, likely related to the sedative profile of the compound

Food Chem Toxicol 71:2632

However, curcumin significantly increased serum progesterone levels ( p = 0.01) in these rats