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One of these studies, the Cardiovascular Outcome Study of Linagliptin versus Glimepiride in Patients with Type 2 Diabetes (CAROLINA), will also test whether linagliptin has a safer cardiovascular profile than the sulfonylurea glimepiride, providing further information related to the long-standing controversy regarding sulfonylurea safety, which was initially raised by the University Group Diabetes Program in the 1970s [9]

63 Role of inflammasome activation in APAP-induced liver injury Inflammasome activation has been implicated in the pathogenesis of various hepatic and systemic inflammatory diseases, including nonalcoholic fatty liver disease, 6769 alcoholic liver disease, 70,71 viral hepatitis, 72 and sepsis-induced liver injury

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doi: 10.1038/mi.2010.62 94 YuHHuangXMaYGaoMWangOGaoTet al

The level of GSR, an essential enzyme that recycles oxidized glutathione (GSSG) back to the reduced form (GSH), was significantly decreased in CKD5 as compared to CVD2 (Figures 3A, I)