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These observations raise the possibility that UBQLN2 is a common catalyst for multiple aggregation-prone proteins, providing a mechanistic link to the frequent co-occurrence of -syn and tau pathologies in PD (Cisbani et al, 2017

Niki E, Noguchi N, Tsuchihashi H, Gotoh N

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Due to the requirement of both delivery efficiency and safety, the majority of drug delivery systems with the ability to cross BBB are designed at a nanoscale level with tailored chemical composition and surface properties (Table 2)

The most explored mechanisms are inflammation, the induction of apoptosis, destruction of the blood-testis barrier, and oxidative stress (34, 35)

167 Lifestyle interventions and mitophagy Exercise interventions, particularly those combining multiple types, such as swimming and interval training, have demonstrated significant potential in enhancing mitophagy in animal models