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Also, beyond its role as a metabolic substrate, -HB functions as a signaling molecule [13, 14]

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Inflammation, repair signaling, angiogenesis, immune modulation, and remodeling occur at the same time

Notably, the proposed binding mode is compatible with the simultaneous binding of the substrate L-Leu- p NA, in agreement with the uncompetitive IRAP inhibition determined for a representative compound