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In recent years, Liu group has made breakthroughs in understanding the characteristics of aging by discovering two novel hallmarks of aging: immunoglobin-associated senescence 22 and endogenous retroviruses resurrection

[284] findings that heat treatment can modify silver nanoparticles geometrical shape, altering their emitted light spectrum wavelength, help put together the most robust explanation so far as to why clinical argyria provisional resolution, at least, can be obtained despite silver persistence in the skin and emphasizes the need not discard the possibility of argyria relapse even with silver exposure discontinuation

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Ultimately, 19 original articles met the inclusion criteria and were used for the final analysis (Figure 1)

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Pharmacol Rep 66:499504 Packer L, Cadenas E (2011) Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling