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The synergistic effects of these agents on monoaminergic modulation, neurotrophic signaling, inflammatory responses, oxidative stress management, and stress-response mechanisms provide a compelling mechanistic foundation for their therapeutic significance in the treatment of depressive disorders

Eur J Pediatr 157(Suppl 2):S40S44 Folbergrov J (1994) NMDA and not non-NMDA receptor antagonists are protective against seizures induced by homocysteine in neonatal rats