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The physical shearing force can tear apart the delicate amino acid chains

Biomed Lett

EAE is predicated on a primary anti-myelin T cell response and therefore disease is most commonly induced by inoculating mice with myelin peptides together with adjuvant to stimulate an immune reaction against these extrinsically-supplied myelin antigens (Robinson et al., 2014)

p16 ink4a is a senescence biomarker that induces cellular senescence through binding of CDK4 and CDK6, which prevents the downstream inhibition of the cell-cycle repressor retinoblastoma-associated protein [4, 45, 46]

We also conducted studies in the SCD mouse model to gain additional evidence for this observation