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Description

IVDD, Intervertebral disc degeneration

The safety data comes from extensive cell studies and animal experimentsnot human trials

J Clin Gastroenterol 2009;43: 3429

Besides, melatonin could directly bind to the MT1 receptor and thus inhibit the production of proinflammatory cytokines such as TNF- and IL-8 in human OA synovial fibroblasts by antagonizing the PI3K/Akt and ERK signaling pathways, subsequently leading to an upregulation of miR-185a expression (140)