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However, despite the discovery of anti-vimentin autoantibodies, other studies refuted that they could have a profound impact on the overall pathogenesis of the disease (99)

8.2.3 Nutrients supporting mitochondrial biogenesis Compounds such as coenzyme Q10 (CoQ10), alpha-lipoic acid, and PGC-1 activators have been shown to promote mitochondrial biogenesis and improve mitochondrial function through various mechanisms

This continuous cycle, combined with elevated expression of -syn, leads to the accumulation of Fe 2+ , resulting in increased ROS production and neuronal toxicity