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It was the first peptide-based obesity drug to produce sustained double-digit weight loss in large randomized trials and served as the benchmark against which all newer incretin molecules are measured

Body weight predicts Nicotinamide N-Methyltransferase activity in mouse fat

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Possible explanations include unacceptable toxicity in human subjects, business strategy changes at Arrowhead Research Corporation (which shifted focus to RNA therapeutics), regulatory challenges, or a combination of factors