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The novel findings in our mouse model lend support to the notion of a detrimental effect of even moderately excessive amounts of FA on prenatal cortical development that can be further aggravated by B 12 deficiency

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Second, the availability of metabolites and other nutrients affects the amount and the proportion of nucleotides produced in cells (Rao et al., 2015), thereby affecting DNA repair and replication

For reconstitution, a larger 3mL syringe is often easiest for handling volumes of 1-2mL

Wisniewska, M., Siponen, M.I., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Kotzsch, A., Moche, M., Nielsen, T.K., Nordlund, P., Nyman, T., Persson, C., Roos, A.K., Schutz, P., Svensson, L., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Schuler, H., Structural Genomics Consortium (SGC) and RCSB PDB

To address this, a standard continuity correction (+0.5) was applied, maintaining model stability