you can have a weak version or a severe version The Rotterdam criteria look for androgen excess, insulin resistance, and polycystic ovaries (but you dont actually need polycystic ovaries to be diagnosed) Androgen excess symptoms: Androgenic or hormonal acne Hirsutism (hair growth on the chin) Deepening of voice Male pattern baldness in females Insulin resistance symptoms: Obesity Pre-diabetes High fasting insulin over 2, or fasting insulin over 6 Androgen dominance often causes oligomenorrhea (intervals longer than 35 days between periods or fewer than 9 periods per year) Infertility red flags: trying for over a year if youre under 35, or over 6 months if youre over 35 Not everyone with PCOS needs Metformin, but its one tool for insulin sensitization Inositol options: myoinositol is an insulin sensitizer, D-chiro-inositol is a weak anti-androgen, and the type of inositol matters depending on whether youre male or female 00:20:13 Cannabis, Alcohol, Testosterone Cannabinoids themselves (THC or CBD) wont reduce testosterone by themselves Smoked marijuana increases your aromatase, which increases estrogen by converting it from testosterone, so that decreases testosterone Increased estradiol works on your pituitary to make less LH and FSH, which means less testosterone release Smoked marijuana acts similarly to opiates in decreasing LH, FSH, and testosterone High alcohol intake decreases testosterone, as does any very potent GABA agonist (barbiturates, benzodiazepines, non-benzos, alcohol) 00:21:47 Males & Testosterone, TRT, Prostate Cancer Testosterone doesnt cause prostate cancer, but normal aging does However, testosterone will grow your prostate cancer if you already have it Wild stat: if youre an 80-year-old male and get an autopsy, theres at least a 50% chance you have prostate cancer, if youre 90-100 years old, its at least 90% For humans with a prostate, its only a matter of time until they get prostate cancer So the real question is: do you want to take something that will definitely grow once you have it? Its an individual assessment
Storage comparison: retatrutide vs other GLP-1 peptides If you have experience storing other peptides, understanding how retatrutide compares helps you calibrate your expectations and apply existing knowledge
Reduces Bone Resorption: Lowers bone turnover markers and helps preserve bone mineral density in androgen-deficient states 4
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This guide covers exact storage durations for different peptide types, optimal refrigerator temperature ranges, proper container and placement strategies, common mistakes that accelerate degradation, and troubleshooting when you suspect cold chain breaks
