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Another approach includes antagomirs which are antisense oligonucleotides chemically modified by conjugation with cholesterol conjugated 2-O-methyl with increased stability

Kanazawa LK, Vecchia DD, Wendler EM, Hocayen PAS, Dos Reis Lvero FA, Stipp MC, et al

In addition, depletion of glutamine, along with other amino acids, triggers the inhibitory eIF2 phosphorylation through GCN2 kinase (Harding et al , 2000)

Because IGF-1 is involved in the hearts response to injury, improves contractility, and reduces cardiac fibrosis, it could be used to improve heart function after myocardial infarction