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Ataxia with isolated vitamin E deficiency is caused by mutations in the alpha-tocopherol transfer protein

Koskela UE, Kuusisto SM, Nissinen AE et al (2013) High vitreous concentration of IL-6 and IL-8, but not of adhesion molecules in relation to plasma concentrations in proliferative diabetic retinopathy

A: Yes, you can stop anytime without health risks or withdrawal effects

[DOI] [PubMed] [Google Scholar] 242.Ma X, et al

doi: 10.7150/ijbs.80324 32 LiJCaoFYinH-LHuangZ-JLinZ-TMaoNet al

this can be explained by the effect of VCN on the enhanced activity of the antioxidant nuclear transcriptional factor Nrf2 (a transcription factor that regulates cell responses to oxidative stress and protects against oxidant injury) as was observed in the gene expression analysis of the lung tissue, and supported by a previous study demonstrating the effect of VCN on oxidative stress-induced hepatotoxicity in vitro and in vivo by stabilizing the Nrf2 and preventing its proteasomal degradation via inhibiting the binding of Keap1 and Nrf2 83