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These discoveries collectively underscore the existence of a complex network of interactions involving the ECM, regulatory immune cells, and CAFs ( Figure 5 )

Burkly, L

Copper peptides are structurally delicate

When Hedgehog binds to PTCH, activated Smo transmits signals through Gli, Sufu, and Kif7, resulting in the generation of the Gli-activated form (GliA), which translocates to the nucleus and leads to transcriptional activation of Hh target genes

PMID: 14647006

DSIP-CBBBP fusion peptide and DSIP treatments demonstrated even more significant increases in neuron density compared to the model group, emphasizing the potential of these treatments in counteracting neuronal loss associated with insomnia