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Balanced duality: H2O2-based therapy in cancer and its protective effects on non-malignant tissues

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Classified as a selective Nicotinamide N-methyltransferase (NNMT) small-molecule inhibitor, this quaternary ammonium compound achieves around 38.4% oral bioavailability in rodent trials, an acceptable absorption rate for positively charged quinolinium derivatives that typically face poor intestinal permeability

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Regulatory monitoring has recorded two serious adverse events in the FDAs FAERS database (2021, 2023) and one life-threatening event in the CAERS database

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