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Another study in the Journal of the American Medical Association notes that among those with diabetic nephropathy (loss of kidney function due to diabetes), combining vitamin B6 (25 mg) and folic acid (2.5 mg) (B-complex vitamin) with 1,000 mcg of oral B12 per day for six years increases the risk of cardiovascular events, including heart attack and stroke

The expression of Piezo1 is highly correlated with tumor microenvironment-related genes that encode proteins involved in ECM organization, angiogenesis, and cell migration (Zhou et al., 2020)