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Somatostatin Feedback Preservation The no-DAC variants short half-life ensures GH is released in discrete bursts that respect somatostatins inhibitory feedback an important distinction in research models where physiological GH axis dynamics and the somatostatin/GHRH interplay are the experimental focus

PubMed Duzel, A., Vlainic, J., Antunovic, M., Malekinusic, D., Vrdoljak, B., Samara, M., Gojkovic, S., Krezic, I., Vidovic, T., Bilic, Z., Sjekavica, I., Djuzel, A.R., Knezevic, M., Sever, A.Z., Lojo, N., Kokot, A., Sever, M., Drmic, D., Seiwerth, S., Sikiric, P

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The peptide incorporates specific amino acid substitutions at key positions to enhance stability against enzymatic degradation while preserving high affinity for the GHRH receptor