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In addition, it is vital to recognize that patients with pernicious anemia will require lifelong vitamin B12 supplementation to prevent the recurrence of hematologic and neurological problems

For the research community this means that clinical doses and durations are not validated , most of todays research protocols rely on animal models and hypothetical extrapolations

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In additional instances, the methods are used in combination with one or more other PD treatment methods, such as deep brain stimulation, administration of levadopa, physical therapy, specialized diets, etc