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Timeline estimates are based on reported outcomes in research settings and will vary between individuals

Cell Reports (2018) 10.1016/j.celrep.2018.05.054 Follow-up study showing that p53 mutations (common in cancer cells) confer resistance to FOXO4-DRI, highlighting the p53-dependent mechanism and the importance of functional p53 for the senolytic effect

Sensorgrams were analyzed using a global fit to the 1:1 Langmuir binding model

Senolytic therapies are typically pulsed short treatment courses with extended rest periods because senescent cell accumulation takes months to years

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As of 2024, we do not typically recommend any particular brand, however we are in the process of sourcing the best glutathione formulation