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(3) suppression of lipid peroxidation via the ACSL4 and SLC7A11 pathways

The probiotic strain Lactococcus lactis MG1363-pMG36e-GLP-1 exerts significant neurotrophic effects on MPTP-induced PD mouse models, and its mechanism is mainly achieved through inhibiting ferroptosis, alleviating oxidative stress, improving intestinal microbiota imbalance, and enhancing intestinal barrier integrity (263)

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Arrestin 3, dynamin and GRK2 also participate to MOR resensitization on the activation of potassium channels in neurons from the locus coeruleus of mice treated during 6 days with morphine (Dang et al., 5 ]-enkephalin exposure (Quillinan et al., 2011)