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According to multiple meta-analyses, MTHFR C677T and A1298C increase the relative risk for high homocysteine, cardiovascular disease, stroke, neural tube defects, certain pregnancy issues, depression, migraines, and some neuropsychiatric conditions, especially with low folate/B vitamins.[ref] These same variants can lower the risk for certain conditions as well, illustrating tradeoffs of both positive and negative effects

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Allosteric Regulation of Neuronal Nitric Oxide Synthase by Tetrahydrobiopterin and Suppression of Auto-Damaging Superoxide

[DOI] [PubMed] [Google Scholar] 8.Hussaini SH, Farrington EA