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10.1186/1465-9921-11-183 195 OhS

Specifically, SM/J mice, known for their poor regenerative capacities, displayed early spontaneous onset IDD that was marked by early onset cellular and matrix changes that were consistent with human IDD, such as loss of NP/AF boundary, formation of small clusters in the NP, and chondrocyte-like cells surrounded by proteoglycan-rich matrix (Choi et al., 2018)